Cosmetic product based on hyaluronic acid with mannitol
Biotime TOPAZ
Product based on hyaluronic acid with mannitol. The presence of mannitol in the composition ensures long-term preservation of the effect after the procedure (the effect after 1-3 procedures lasts an average of 6 months, instead of 1-2 weeks)
Release form
Vial 3 ml

HA concentration 1.25% (12.5 mg/ml) unstabilized + mannitol 4% + buffer  Molecular weight 1 million Daltons 
  • The drug is an ideal remedy for patients with a symptom complex of "tired", "stressed" skin, including a dull gray complexion for patients with a finely wrinkled type of aging.
  • Signs of chrono-, photoaging.
  • Dehydration due to prolonged exposure to sunlight or UV rays, or as a result of frostbite.
  • Mimic wrinkles, loss of skin elasticity.
  • The introduction of the gel into the skin of the eyelids is not allowed.
  • The introduction of the gel into the blood vessels (intravascular ingestion) is not allowed.
The use of the gel is not allowed
  • In patients with known hypersensitivity to hyaluronic acid and/or mannitol;
  • In patients with a tendency to develop hypertrophic scars;
  • In patients with known hypersensitivity to hyaluronic acid;;
  • In pregnant and lactating women;
  • In persons under 18 years of age.
  • The gel should not be injected into areas of the skin prone to inflammation and / or infection (acne, herpes, etc.). 
  • Hyaluronate 1.25% (1 Million Da)
  • Mannitol 4%
  • Buffer solution
Protocol of procedures

Areas of application

The drug is administered evenly from the center to the periphery (avoiding the periorbital area), along wrinkles, along the contour of the street, in the area of the cheekbones, nasolabial folds, along the longitudinal and pepper wrinkles of the forehead. In the décolleté area, the drug is injected along V-shaped lines, diverging from the middle of the sternum to the collarbones. On the neck, the drug is injected along the horizontal lines of the folds. In the area of the hands from the phalanges of the fingers linearly (fan) to the wrist.

Recommended courses:

  • Reinforced course: 3-5 procedures with an interval of 10-15 days;
  • Maintenance course: 1 procedure with an interval of 4-6 weeks.

Precautionary measures:

  • Do not use after the expiration date indicated on the package;
  • For single use only;
  • If the package is open or damaged, do not use its contents.